IMMUNOLOGICALLY ACTIVE POLYSACCHARIDES in Agaricus subrufescens | Polysaccharides In Agaricus Subufescens

IMMUNOLOGICALLY ACTIVE POLYSACCHARIDES in Agaricus subrufescens | Polysaccharides In Agaricus Subufescens

IMMUNOLOGICALLY ACTIVE POLYSACCHARIDES in Agaricus subrufescens 

  • Various ╬▓-and ╬▒-linked glucans, Glucomannan, Riboglucan.
  • Polysaccharides from Agaricus bisporus and Agaricus brasiliensis show similarities in their structures and their immunomodulatory effects on human monocytic THP-1 cells.
  • Mushroom polysaccharides have traditionally been used for the prevention and treatment of a multitude of disorders like infectious illnesses, cancers and various autoimmune diseases. 
  • Crude mushroom extracts have been tested without detailed chemical analyses of its polysaccharide content. 
  • For the present study we decided to chemically determine the carbohydrate composition of semi-purified extracts from 2 closely related and well known basidiomycete species, i.e. Agaricus bisporus and A. brasiliensis and to study their effects on the innate immune system, in particular on the in vitro induction of pro-inflammatory cytokines, using THP-1 cells.

Polysaccharides In Agaricus subrufescens
Polysaccharides In Agaricus subrufescens

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