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Chronic diseases, the primary cause of death and disability, have drawn much attention.
In exploring novel side-effect-free agents against chronic diseases, great efforts have been devoted to mushroom polysaccharides due to their diverse biological activities.
In this work, the structural features, biological performances, and molecular mechanisms of mushroom polysaccharides in the management of cancers, diabetes mellitus, and cardiovascular diseases were reviewed.
The potentials of mushroom polysaccharides against chronic diseases highly depend on their structural features, including monosaccharide composition, molecular weight, the type and configuration of glycosidic bonds, degree of branching, the type of substituent pattern, and chain conformation.
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