Ganoderma lucidium (GL) is a frequently mentioned mushroom that has been reported to reduce obesity in mice by modulating the composition of gut microbiota.
GL reduces body weight, inflammation, and insulin resistance in mice fed a high-fat diet.
The GL not only reverses gut dysbiosis—as indicated by the reduced firmicutes/Bacteroidetes ratios and endotoxin-bearing Proteobacteria levels—but also alters the intestinal barrier probity and attenuates endotoxemia.
The results confirm that GL can be used as a prebiotic agent to prevent gut dysbiosis and obesity-related metabolic disorders in obese individuals.
Mushrooms are shown to improve the antioxidant status via microbiome alterations.
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